The day before yesterday (2023-3-18) at a meeting with a wife club, a friend told me that his friend had fatty liver and cirrhosis, so I wonder if there was any way to reverse it. I told him, yes, use exercise to increase heat consumption and reduce...
The day before yesterday (2023-3-18) at a meeting with a wife club, a friend told me that his friend had fatty liver and cirrhosis, so I wonder if there was any way to reverse it. I told him, yes, use exercise to increase heat consumption and reduce heat consumption with diet.
In fact, the American Medical Association journal JAMA happened to publish a clinical research paper on the reversal of fatty liver on the day before, so I translated its focus as follows:
Title: Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease (The impact of limited time diet on non-alcoholic fatty liver disease).
Research machine: Nonalcoholic Fatty Liver Disease (NAFLD) has become the world's major public health challenge. It affects about 20% to 30% of adults in the general population, and more than 70% of people with obesity and diabetes have NAFLD. In China, about 29.2% of adults in the general population suffer from NAFLD. It is closely related to obesity, type 2 diabetes, hyperlipidemia and hypertension, and is associated with increased risk of cardiovascular disease. Reducing weight by changing lifestyle has been shown to improve liver fat and epilepsy disorders.
Restriction of dietary heat has been shown to effectively reduce body weight and liver lipid levels in patients with NAFLD. However, it is difficult to keep changing your lifestyle for a long time. Time-Restricted Eating (TRE) is one of the most popular intermittent fasting regimens, involving specific eating times over a 24-hour cycle. The TRE scheme is gaining attention because it can reduce weight and increase dependence. Studies on urinary animals have shown that eating time, rather than calorie intake, is the basis for the beneficial effects of the TRE regimen. There are evidence that fat storage increases during the day and increases the most after dinner. Observative studies show that eating later in the day may be related to the success of human fat loss methods. Several trials reported that TRE can reduce calorie intake and is related to weight and fat in obese patients. However, most reported TRE benefits are not tested or under-tested in the human body and cannot distinguish the effects of TRE itself. A small clinical trial report reported during the 12-week dry expectation of 54 Type 2 diabetes. The regimen of eating 2 meals (from 6:00 a.m. to 4:00 p.m.) decreased liver fat compared to the control regimen (eating a 6-ton meal). So far, the effectiveness of TRE for NAFLD is not yet determined. Furthermore, to the best of our knowledge, no study has been conducted on the effects of comparing TRE and Daily Calorie Restriction (DCR) on the liver lipid levels in patients with NAFLD.
Non-alcoholic fatty liver disease limited time nursing (TREATY-FLD) random clinical trials were designed to compare the effects of TRE and DCR on intrahepatic triglyceride (IHTG) content and epidemiological risk factors in obese and NAFLD patients. We assume that 8 hours TRE is more effective than DCR in improving NAFLD and renunciation risk factors.
Study subjects: A total of 88 patients aged between 18 and 75 years old (average 32 years old, 49 men), with body mass index between 28.0 and 45.0 (average 32.2), and were included in this study by MRI. 45 of them were randomly assigned to the TRE group, and the remaining 43 were assigned to the DCR group.
Research Methods: All participants were instructed to follow a diet of 1500 to 1800 kcal/d for males and 1200 to 1500 kcal/d for females. Diet consists of 40% to 55% carbohydrates, 15% to 20% protein, and 20% to 30% fat. During the first 6 months, all participants received 1 serving of protein hand-drinks daily and were given dietary consultations during the study period. Participants assigned to the TRE group are instructed to consume prescribed calories from 8:00 a.m. to 4:00 p.m. daily and allow only hot-free drinks outside the daily diet window. Participants in the DCR group did not have a diet time limit during the 12-month study period. All participants took a monthly health education course for 12 months and were told not to change their physical activity habits throughout the trial.
The main result was to measure changes in IHTG content from baseline to 6 months and 12 months. IHTG content was measured using NMR at baseline, 6 months and 12 months. The secondary results were changes in body weight, BMI, waist, body fat mass, leukemia, liver enzyme levels, and other epidemiological risk factors, including blood glucose levels, blood lipid levels, and blood pressure.
Results: At 6 months, the IHTG content of the TRE group decreased by 8.3%, while the DCR group decreased by 8.1%.. At 12 months, the IHTG content of the TRE group decreased by 6.9%, while the DCR group decreased by 7.9%. In addition, the liver cirrhosis, weight and credit risk factors were significantly reduced in both groups.
Conclusion: In adults with obesity and NAFLD, TRE did not produce additional benefits in reducing IHTG content, body lipids, and epidemiological risk factors compared with DCR. These findings are exactly the opposite of our assumption, that is, reducing heat intake rather than limiting eating time is a beneficial measure for improving fatty liver.
