The American Medical Association journal JAMA published the Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength on August 27, 2019. I translated its first and third paragraphs separately as follows: Vitamin D s...
The American Medical Association journal JAMA published the Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength on August 27, 2019. I translated its first and third paragraphs separately as follows:
Vitamin D supplements are considered beneficial for preventing and treating bone dysfunction. Clinical trial data support vitamin D supplementation for bone benefits in people with vitamin D levels below 30 nmol/L. However, recent saccharide analysis does not support the main therapeutic benefit of vitamin D for bone retardation or prevention of falls or fractures. Most recommended doses for vitamin D supplementation are between 400 and 2,000 International Units (IU) per day, while the acceptable upper limit is between 4,000 IU and 10,000 IU. According to the survey, between 2013 and 2014, 3% of U.S. adults took at least 4,000 IU of vitamin D daily. However, a study found that the impact of 6500 IU on bone density (BMD) is not different from 800 IU.Considering the general phenomenon of large doses of vitamin D supplementation for healthy adults, this study explored the effect of daily vitamin D supplementation (400, 4000, 10,000 IU) on bone density and bone strength of healthy community residents over three years. Our expectation is that high dose vitamin D will have a positive effect on bone density and bone strength.
This study was a double-blind random clinical trial conducted in Calgary, Canada from August 2013 to December 2017, with 311 healthy community-based adults without osteoporosis (male 165, female 146), aged 55 to 70 years old. Among them, 109 people took 400 IU of vitamin D3 daily, and the other 100 people took 4000 IU daily, while the remaining 102 people took 10,000 IU daily. The result is:
1. In the forearm bone density, the average person who took 400 IU decreased by 1.2%, the average person who took 4000 IU decreased by 2.4%, while the average person who took 10,000 IU decreased by 3.5%.
2. In the calf bone density, the average person who took 400 IU decreased by 0.4%, while the average person who took 4000 IU decreased by 1.0%, while the average person who took 10,000 IU decreased by 1.7%.
3. In terms of bone strength, people taking vitamin D supplements also showed a decline in trend, but did not achieve a statistically significant meaning.
I published a year ago in "The Biggest Analysis in History: Vitamin D is Useless" that supplementing vitamin D will not increase bone density or reduce fractures. I have also provided a large amount of medical literature to prove that vitamin D supplements are useless. I even published "Calcium and Vitamin D supplements increase death risk." Now this study also points out that vitamin D supplementation can reduce bone density.
Then, do you still have to persist?
Original text: high dose vitamin D→ low density bone quality
